50-100 mg daily of 5-HTP is safe and effective dosage without any side effects. Experiments have been carried out with 300 mg dose per day but some people may experience minor discomfort at these higher dosages.

ost people will get its benefits at 50 mg dose and might occasionally need 100 mg. Most of the market preparations are available with 20, 30 and 50 mg dosage.

The best method to take it is empty stomach and with water. However, you can take it a few minutes before meal or breakfast.

The dosage and time to take 5-HTP depends on what you are taking it for. Taking it empty stomach might increase its absorption. People, who are taking it to reduce anxiety or depression, can take it anytime of the day or night. Persons, who use it for weight loss, should take it always one or half hour before meals. Sleep troubles are better relieved by taking it in the evening.

5-HTP and Higher Dosage:

A placebo-controlled, double-blind study reported in 1992 found excellent results treating obesity using 900 mg 5-HTP daily without a PDI, with minimal side effects!

C. Cangiano, et al. Eating Behavior and Adherence to Dietary Prescriptions in Obese Adult Subjects Treated with 5-Hydroxytryptophan. Is J Clin Nutr 1992; 56: 863-7?

The Pro and Cons Of 5-HTP with Vit B6:

There are different thoughts regarding vitamin B6 use with 5-HTP without arriving at any conclusion. The supporters of Vitamin B6 cites that the conversion of 5-HTP to serotonin is facilitated. So people are advised to take 5-HTP with Vit. B6.

The opposite view maintains that it is beneficial to have more serotonin in brain that might have positive effects on mental health. They maintain that when it will be present in greater concentration in blood stream, it would cause many distressing symptoms. There is no conclusive decision; the matter is turned more confusing.

The practical method is to check it yourself. If you are comfortable taking it with Vit. B6, Continue both of them; otherwise discontinue its use with Vit. B6.